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Harvey Cantor
Harvey Cantor is an American immunologist known for his studies of the development and immunological function of T lymphocytes.〔National Academy of Sciences |http://www.nasonline.org/member-directory/members/20002178.html〕 Cantor is currently the Baruj Benacerraf Professor of Microbiology & Immunobiology at the Harvard Medical School and Chair of the Department of Cancer Immunology & AIDS at the Dana-Farber Cancer Institute in Boston, Massachusetts.〔(【引用サイトリンク】url=http://hms.harvard.edu/faculty-search?LastName=cantor&id=BX8WUX8BbxI= )〕
== Research ==
Cantor’s early studies focused on the development and function of lymphocytes derived from the thymus (T-lymphocytes or T cells). In particular, his research addressed whether the multiple immunological functions of T cells were invested in a single lineage or represented the specialized activities of distinct T cell subsets.〔Cantor H, Boyse EA. Functional subclasses of T-lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T-cell subclasses is a differentiative process independent of antigen. ''J. Exp. Med.'' 1975;141:1376.〕〔 Cantor H, Boyse EA. Functional subclasses of T-lymphocytes bearing different Ly antigens. II. Cooperation between subclasses of Ly+ cells in the generation of killer activity. ''J. Exp. Med.'' 1975;141:1390.〕〔 Huber B, Cantor H, Shen F-W, Boyse EA. Independent differentiative pathways of Ly1 and Ly23 subclasses of T-cells. Experimental production of mice deprived of selected T-cell subclasses. ''J. Exp. Med.'' 1976;144:1128.〕〔Nabel G, Fresno M, Chessman A, Cantor H. Use of cloned populations of mouse lymphocytes to analyze cellular differentiation. ''Cell'' 1981;23:19.〕〔Rao A, Allard WJ, Hogan PG, Rosenson RS, Cantor, H. Alloreactive T cell clones. Ly phenotypes predict both function and specificity for major histocompatibility complex products. ''Immunogenetics'' 1983;17:147.〕 This approach depended on the use of antibodies to cell surface glycoproteins or “markers” that might identify specialized subsets of lymphocytes with particular immunologic functions.〔Boyse EA, Old LJ, Stockert E. An approach to the mapping of antigens on the cell surface. ''Proc Natl Acad Sci USA'' 1968;60:886.〕 This experimental approach was also used to investigate other lymphocyte populations, including “natural killer” cells.〔Glimcher L, Shen F-W, Cantor H. Identification of a cell-surface antigen selectively expressed on the natural killer cell. ''J. Exp. Med.'' 1977;145:1.〕 His laboratory continues to investigate the molecular and cellular elements that regulate the immune response and maintain self-tolerance. 〔†Hu D, †Ikizawa K, Lu L, Sanchirico ME, Shinohara ML, Cantor H. Analysis of regulatory CD8 cells in mice deficient in the Qa-1 class Ib molecule. ''Nature Immunology'', 2004;5:516〕〔Lu L, Ikizawa K, Hu D, Werneck MBF, Wucherpfennig KW, Cantor H. Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway. ''Immunity'', 2007;26: 593〕〔†Leavenworth JW, †Schellack C, †Kim H-J, Lu L, Spee P, and Cantor H. Analysis of the cellular mechanism underlying inhibition of EAE after treatment with anti-NKG2A F(ab)′2. ''Proc Natl Acad Sci USA'', 2010;107:2562 〕〔Kim H-J, Verbinnen B, Tang X, Lu L and Cantor H. 2010. Inhibition of follicular T helper cells by CD8+ Treg is essential for self tolerance. ''Nature'' 2010;467:328〕〔Kim, H-J, Wang X, Radfar S, Sproule TJ, Roopenian DC, Cantor H. CD8+ T regulatory cells express the Ly49 class I MHC receptor and are defective in autoimmune prone B6-Yaa mice. ''Proc Natl Acad Sci USA'' 2011;108:2010〕〔†Leavenworth JW, †Wang X, Wenander CS, Spee P, Cantor H. Mobilization of natural killer cells inhibits development of collagen-induced arthritis. ''Proc Natl Acad Sci USA'' 2011;108:14584〕〔Leavenworth JW, Tang X, Kim HJ, Wang X, Cantor H. Amelioration of arthritis through mobilization of CD8+ regulatory T cells. ''J Clin Invest'', 2013;123:1382-9〕
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